"Imunoglobulina na patogenia da leishmaniose visceral em hamsteres" Immunoglobulin in the pathogenesis in visceral leishmaniasis in hamsters

by Mathias, Regiane

Pathogenesis of tissue lesions in visceral leishmaniasis (VL) was searched in hamsters infected with Leishmania (Leishmania) chagasi amastigotes. Internalization of IgG from VL hamsters by human umbilical vein endothelial cells was observed in vitro and in liver and kidney in hamsters VL, under transmission electron microscopy, at 30 and 60 days of infection. Increased vascular permeability was observed at 60 days of infection in VL hamsters, and purified IgG from VL hamsters induced permeability increase in normal hamsters. These data suggest the internalization of IgG by endothelial cells as an alternative mechanism involved in the pathogenesis of tissue lesions in VL.