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Implantation of biocompatible fibers for the coupling of muscle groups [electronic resource] /

by Franklin, Jeff E.; Theses and, OhioLINK Electronic

Abstract (Summary)
Implanting poly(ethylene terephthalate) (PET) in muscle may not seem to have any relevance in the medical industry, but it is shown in this dissertation, that the significance is extraordinary. Specifically it is shown that PET, in the fiber form, can be used to repair muscle and reattach muscle to bone. From the results shown in the rabbit model, this new device and method out performed the standard suture technique not only in wound strength, but in the post-implantation histology of the muscle as well. The results for the wound strength test are: the average max load for the control specimens were 47.63 ± 16.87 N, while the experimental specimens had an average of 75.3 ± 17.5 N. The results for the destructive aspect of this study were very conclusive. While testing the samples, it was noted that the experimental samples, the muscle itself, tore away from the tissue closure, while the closure remained intact. The control samples failed not only in the location of the surgical incisions, but some, very few in fact, failed in other locations rather than the surgical incision. Based upon these results and the results shown in the histological optical micrographs, the FiberSecureTM device out perform the regular suturing technique. Being able to connect to muscle tissue with certainty also has other benefits: such as the ability to create artificial tendons. A revolutionary biomedical device is presented here with the utilization of this fiber technology. As shown, the bond between the muscle and fiber is stronger than the base muscle tissue; therefore, the artificial tendon will not slip as is the current method's deficiency.
Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:university of cincinnati

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