Immunoglobulins: structure, genetics, and evolution

by Hood, Leroy E.

Abstract (Summary)
The immune system is capable of generating an immense number of different antibody molecules. The nature of the genetic machinery responsible for this diversity has been studied by selective amino acid sequence analysis of homogeneous immunoglobulin light chains (derived from myeloma tumors). The evolution of the immune system has also been examined through chemical studies of normal pooled light chains derived from various mammalian and avian species. These studies place constraints on proposed genetic mechanisms for antibody diversity. The theories, the structural constraints, and the evolutionary implications of these observations are discussed.
Bibliographical Information:

Advisor:W.J. Dreyer

School:California Institute of Technology

School Location:USA - California

Source Type:Master's Thesis



Date of Publication:11/29/1967

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