Host Defense Mechanisms Against Mycobacterium Tuberculosis
Mycobacterium tuberculosis is one of the world™s most infectious diseases. Approximately 2 million people die each year from Mycobacterium tuberculosis infection and one-third of the world™s population remains infected. For decades research has focused on uncovering the tactics used by Mycobacterium tuberculosis to evade host immune responses and defense mechanisms used to fight tuberculosis infection. The following review focuses on the host defense mechanisms used to combat Mycobacterium tuberculosis with an emphasis placed on the roles that Toll-like receptors (TLRs), T cells (gamma delta, CD4, CD8), and macrophages play in mounting the innate and adaptive immune responses necessary to eradicate this disease. The challenges of designing an effective vaccine to fight Mycobacterium tuberculosis infection and the two first-line anti-tuberculosis inhalant drugs, Isoniazid (H) and Rifampicin (R) are also discussed.
School:Wright State University
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:mycobacterium tuberculosis host defense mechanisms
Date of Publication:06/30/2009