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High Prevalence of the Metabolic Syndrome and Associated Left Ventricular Hypertrophy in Pediatric Renal Transplant Recipients

by WILSON, AMY C.

Abstract (Summary)
Background: Individual cardiovascular (CV) risks are common after pediatric renal transplant. The prevalence of metabolic syndrome and its association with CV abnormalities are unknown in this population. Methods and Results: Multi-center retrospective review was performed at time of and at 1-year post transplant for 256 consecutive patients. 37.6% met diagnostic criteria for metabolic syndrome at 1-year post transplant. Among 181 patients with complete data at both time points, 18.8% met diagnostic criteria at time of transplant, versus 37.0% at 1-year (p2.7 versus 40.0g/m2.7 (p=0.0008) in those without. Left ventricular hypertrophy (LVH) was more common in those with metabolic syndrome (55% versus 32%) (OR 2.6, 95% CI 1.2-5.9). Conclusions: Metabolic syndrome is common at time of pediatric renal transplant, and prevalence rises sharply at 1-year post transplant. Metabolic syndrome is associated with increased LVMI and LVH in this population.
Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:pediatric renal transplant metabolic syndrome left ventricular hypertrophy

ISBN:

Date of Publication:01/01/2008

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