"Hepatitis B Among Pregnants attended by the Pre-Natal Program of the Municipal Secretary of Health of Ribeirão Preto: Prevalence of Markers and Care Provided to the New-borns."

by Perim, Eduardo Brás

Abstract (Summary)
It is estimated that about 400 million persons are chronic carriers of the hepatitis B virus worldwide. When it occurs in adults, the disease shows high proportions of benign evolution, meanwhile in vertical transmission the risk of becoming a chronic carrier approaches 90%, elevating the possibilities of serious consequences to the child, including cirrhosis and primary hepatocellular carcinoma. The possibility of performing screening tests for the identification of pregnant women carriers of the hepatitis B virus and the consequent adoption of prophylactic measures ? active and passive immunization ? allow safe prevention of the vertical transmission. In 1999, the Pre-Natal Program of the Municipal Secretary of Health of Ribeirão Preto, SP, Brasil, included in its routine services the screening for the HBsAg, towards the identification of pregnant carriers of the virus. This study aims to look into some aspects referring to hepatitis B among the pregnants being attended by the Municipal Health Network, as well as perform a careful systematic evaluation of the Pre-Natal Program. In order to perform this study, two groups of pregnants were selected. The first one formed by those patients having had their first pre-natal serological evaluation done for that pregnancy during the period of November 1, 2001 until October 31, 2002, with the purpose of estimating the HBsAg prevalence and also to verify the proportion of the new-borns of HBsAg carriers that received the recommended care for that situation. The second group was formed by those patients on the same condition, evaluated during the period of July 1, 2002 until June 30, 2003, with the purpose of also estimating the HBsAg prevalence, as well as estimating the proportion of HBeAg and anti-HBe carriers. The HBsAg prevalences were the following: for the first group of pregnants 0,5 (CI 95% : 0,3 ? 0,7) and 0,4 (CI 95%: 0,2 ? 0,6) for the second one. It was verified that in 25,0% of the 24 births that happened in the city, the recommended care were not taken, when it comes to the prompt request of the specific vaccine and immunoglobulin. This fact was, partially, due to deficiency in the data files quality of the different institutions. The proportions of HBeAg and anti-HBe carriers found were, respectively, 5,9% (CI 95%: 0 ? 17,1) and 90,5% (CI 95%: 77,9 ? 100). This study intends to present data that can be the starting point towards reflections on the established procedures of the Pre-Natal Program, in order to increase its effectiveness and surpass the found obstacles.
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Afonso Dinis Costa Passos; Afonso Dinis Costa Passos; Marisa Marcia Mussi Pinhata; Arthur Watanabe

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis

Keywords: assessment of health programs hepatitis B immunoprophylaxis imunoprofilaxia pregnants prevalence


Date of Publication:02/17/2004

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