HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations.

by Ernstoff, Elana Ann

Abstract (Summary)

Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ?s biology and rapid mutation rate have made vaccine design difficult. We examined HIV-1 subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon sites under positive selection and epitope regions

Bibliographical Information:

Advisor:

School:University of the Western Cape/Universiteit van Wes-Kaapland

School Location:South Africa

Source Type:Master's Thesis

Keywords:hiv subtype c cytotoxic t lymphoctyes ctl human leukocyte antigen hla

ISBN:

Date of Publication:01/01/2002