HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations.
Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ?s biology and rapid mutation rate have made vaccine design difficult. We examined HIV-1 subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon sites under positive selection and epitope regions
School Location:South Africa
Source Type:Master's Thesis
Keywords:hiv subtype c cytotoxic t lymphoctyes ctl human leukocyte antigen hla
Date of Publication:01/01/2002