Gain pondéral et antipsychotiques de seconde génération : comportements alimentaires et risque cardiovasculaire
Second génération antipsychotics (SGA) induce substantial weight gain but the mechanisms responsible for this phenomenon remain spéculative. Objective: To explore eating behaviours among SGA-treated patients and compare them to non-schizophrenic healthy sedentary individuals (controls). Research Methods and Procédures: Appetite sensations were recorded before and after a standardized breakfast using visual analogue scales. Three hours after breakfast, a buffet-type meal was offered to participants to document spontaneous food intake and food préférences. Satiety quotients were calculated to détermine the satiation of both meals and the Three-Factor Eating Questionnaire was used to document eating behaviours. Body composition and abdominal fat distribution were assessed. Results: Compared to controls (n = 20), SGA-treated patients (n= 18) showed greater adiposity indices (p < 0.04). Patients' degree of hunger was also higher following the standardized breakfast (p = 0.03). Moreover, patients had significantly higher cognitive dietary restraint, disinhibition and susceptibility to hunger scores than the référence group (p < 0.05). Disinhibition in the référence group was positively associated with hunger triggered by external eues (r = 0.48, p = 0.03) where as internai eues seem to mainly regulate emotional susceptibility disinhibition in patients (r = 0.56, p = 0.02). In patients, higher stratégie restraint behaviour was associated with decreased satiation right after the buffettype meal (r = -0.56, p = 0.02). Discussion: Thèse exploratory findings suggest that patients under SGA seem to develop disordered eating behaviours in response to altered appetite sensations and increased susceptibility to hunger, a factor which may influence the extent of body weight gain triggered by thèse drugs.
Advisor:Almeras, Natalie; Richard, Denis
School Location:Canada - Quebec / Québec
Source Type:Master's Thesis
Date of Publication:04/01/2008