Formulation of a fast-acting ibuprofen suspension by using nicotinamide as hydrotropic agent - application of DSC, spectroscopy and microscopy in assessment of the type of interaction
The purpose of this study was to examine the nature of the solid-state interaction between ibuprofen and nicotinamide and determine the solubility enhancement achieved by using nicotinamide as a hydrotropic agent and develop a suitable efficacious formulation. Ibuprofen-nicotinamide binary mixtures were prepared by solvent evaporation method. DSC studies suggested complex formation between ibuprofen and nicotinamide with 1:1 stoichiometry in solid state. UV-Visible spectroscopy suggested that the interaction was weak. Disappearance of the broad hydrogen bonding peak in the FTIR spectrum for the complex predicted greater solubility for the complex. Proton NMR studies ruled out the possibility of any chemical interaction between the two compounds. PXRD and microscopic studies showed that the crystallinity of the complex was remarkably reduced. All the studies predicted greater solubility for ibuprofen in complexed form. The HPLC studies showed that solubility was enhanced 62 times in the suspension when the concentration of nicotinamide was 13.3 mg/mL.
School:University of Toledo
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:ibuprofen nicotinamide hydrotropy spectroscopic solubility enhancement
Date of Publication:01/01/2004