Finite element analysis of interaction between actin cytoskeleton and intracellular fluid in prechondrocytes and chondrocytes subjected to compressive loading [electronic resource] /

by Viswanathan, Sundar

Finite element analysis of interaction between actin cytoskeleton and intracellular fluid in prechondrocytes and chondrocytes subjected to compressive loading Prechondrocytes exhibit a change in their actin cytoskeletal arrangement when subjected to loading. This study looks at the implications of the altered solid- fluid interactions due to this change. A 2-D Finite element model of a cell was developed. A solid-fluid interaction solution procedure was validated and used to determine fluid flow/pressure in a cell when subject to deformation. These values were then used to calculate fluid flow induced stresses on individual actin fibers. The results suggest that prechondrocytes alter their cytoskeletal structure to reduce stresses as a result of fluid flow due to deformation of the cell. This thesis is dedicated to my parents - iii -