Facteurs de risque de la maladie cardiovasculaire chez les patients atteints d'une maladie pulmonaire obstructive chronique
Chronic obstructive pulmonary disease (COPD) is frequently associated with comorbidities
leading to cardiovascular diseases. Of note, cardiovascular diseases
are one of the three most important causes of mortality in patients with COPD.
However, the mechanisms responsible for cardiovascular diseases in COPD
patients remain largely spéculative. The aim of this thesis is to evaluate the risk
factors of cardiovascular diseases, mainly the metabolic syndrome and arterial
hypertension, in COPD patients. Firstly, we showed that the metabolic syndrome
is encountered more often in COPD patients compare to control subjects and we
observed that a large proportion of COPD patients presented high blood pressure.
To confirm thèse results, we undertook a study comparing the increase in blood
pressure during exercise between COPD patients and control subjects. The
results of this study showed that blood pressure increases quickly at low levels of
exercise in patients with COPD compared to subjects without respiratory diseases.
Consequently, we undertook two others studies. The first was a clinical trial
evaluating the effects of aérobic exercise training alone or with an antihypertensive
médication (Irbesartan) on blood pressure and heart rate variability in patients with
Advisor:Poirier, Paul; Maltais, François
School Location:Canada - Quebec / Québec
Source Type:Master's Thesis
Date of Publication:07/01/2008