Expression of matrix metalloproteinases MMP-2, TIMP-2 e MT1-MMP and clinicopathologic aspects in medullary thyroid carcinoma: prognostic implications

by Cavalheiro, Beatriz Godoi

Abstract (Summary)
Metalloproteinases (MMP) are proteolytic enzymes, fundamental to carcinogenesis. Outcome of 37 patients operated on due to medullary thyroid carcinomas were compared to clinicopathologic data and immunohistochemistry expression of MMP-2, MT1-MMP and TIMP-2 in their neoplastic specimens. Final clinical conditions were related to the clinicopathologic aspects: clinical features, systemic symptoms, tumor size, tumor extension to thyroid capsule, tumor extension to adjacent tissues, vascular invasion, cervical metastases, TNM stage and evidences of disease in the neck and/or distant metastases. Expression of MMP-2 and MT1-MMP were related to outcome and greater proportion of TIMP-2, over MMP-2, was related to prognostic benefits
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Lenine Garcia Brandao; Vergilius José Furtado de Araujo Filho; Roberto Pereira de Magalhães; Rui Celso Martins Mamede; Alfio José Tincani; Lenine Garcia Brandao

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis

Keywords:Carcinoma medullary Gelatinase A Immunohistochemistry Imunohistoquímica Metalloproteases Metaloproteases Prognosis Thyroid neoplasms Tissue Inhibitor of Metalloproteinase-2


Date of Publication:04/24/2006

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