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Experimentelle und klinische Untersuchungen über den Gebrauch von Allograft-Material zur in situ-Behandlung von Infektionen im Bereich der Aorta

by Knosalla, Christoph

Abstract (Summary)
Infections of the aorta remain one of the most dreaded complications in reconstructive vascular surgery. The purposes of this study were to evaluate the efficacy of a cryopreserved aortic allograft to treat an established vascular graft infection by the surgical in situ replacement of the infected segment in an animal model, and to investigate the role of antibiotics to decontaminate the allograft during the cryopreservation process. Furthermore, the tissue concentrations of the antibiotic and the kinetics of desorption were investigated in in vitro experiments. A model of prosthetic graft infection by Staphylococcus epidermidis RP-62 (inserted in the infrarenal aorta) in dogs was developed. By in situ replacement of the infected prosthetic graft with a cryopreserved aortic allograft, this study demonstrated an intrinsic resistance to infection of cryopreserved aortic allografts. However, antibiotic loading of the cryopreserved aortic allografts appeared to be essential to obtain optimal therapeutic effects. The results of these in vivo experiments were supported by the findings of our in vitro studies, as well by analysis of our own clinical results and by clinical data published in the medical literature. We conclude that in situ replacement with a cryopreserved allograft is currently the therapy of choice for an aortic infection.
This document abstract is also available in German.
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The full text for this document is available in German.
Bibliographical Information:

Advisor:

School:Humboldt-Universität zu Berlin

School Location:Germany

Source Type:Master's Thesis

Keywords:Allograft Kryokonservierung Aorteninfektion allograft cryopreservation aortic infection mycotic aneurysm

ISBN:

Date of Publication:06/27/2001

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