Evaluation of Sensorimotor Deficits and Compensatory Mechanisms Following Traumatic Brain Injury Using Three-Dimensional Kinematic Analysis in Rodent Models

by Myerson, Connie Elka

Three-dimensional kinematic analysis was used to precisely quantify alterations in gait and compensatory behaviors in rat performance on beamwalk and treadmill tasks following moderate traumatic brain injury. Measures included limb height, joint angles, adduction, flexion, and swing/stance phase duration. Injury-associated changes on the treadmill included postural and hip angle change, and increases in hip height and adduction. The beamwalk presented as a more sensitive measure when coupled with kinematic analysis, as differences between injury groups were evident on measures including knee, ankle, elbow, and mid hip height. Animal response was diverse, possibly reflecting individual compensatory strategies which varied among injured animals. Kinematic analysis was ultimately shown to be a useful tool in characterizing and dissociating initial impairment, compensation, and recovery.