Evaluation of Golden Retriever dogs with muscular dystrophy (GRMD) by tissue Doppler imaging (TDI), Strain Rate and Strain
Tissue Doppler imaging (TDI), strain rate, and strain allow for recording myocardial velocity and deformity, for assessment of systolic and diastolic function. There is great similarity between Duchennes muscular dystrophy (DMD) that affects humans, characterized by continuous degeneration, necrosis and fibrosis of skeletal and cardiac muscle and is recessive, linked to X-chromosome, and canine muscular dystrophy (CMD), which is considered genetically analogous to the DMD. Some experimental models have been developed in order to study these diseases. In this study, 24 Golden retriever dogs, allocated to 3 different groups (control, bearer and affected) were evaluated by conventional echo and TDI, strain rate (StR) and strain (St) aiming to evaluate systolic and diastolic function indices of dystrophic dogs in order to improve diagnosis and treatment of DMD cases, as well as CMD. Differences were observed in some variables of systolic and diastolic function specially between control and affected groups. It was possible to confirm that Golden Retriever dogs, affected by CMD and without clinical signs of congestive heart failure, present changes in systolic and diastolic indices, detected by TDI, StR and St.
Advisor:Maria Helena Matiko Akao Larsson; Moacir Leomil Neto; Silvia Regina Ricci Lucas; Lilian Emy dos Santos Michima; Denise Saretta Schwartz; Maria Helena Matiko Akao Larsson
School:Universidade de São Paulo
Source Type:Master's Thesis
Keywords:Dogs Doppler Echocardiography Muscular dystrophy Tissue
Date of Publication:12/12/2008