Details

Estimativa da efetividade da vacina contra coqueluche em domicílios localizados em áreas assistidas pelo Programa Nacional de Imunizações em Pernambuco, Brasil

by Baptista Filho, Paulo Neves

Abstract (Summary)
The secondary attack rates had been used to estimate the pertussis whole-cell vaccine effectiveness in households in areas assisted by the National Immunization Program, Pernambuco, Brazil. The 57 households had been identified by the index cases assisted in the Paediatric Infectious Diseases Service at the Oswaldo Cruz Hospital. Pertussis as defined by the Center for Diseases Control and Prevention - U.S.A. was diagnosed in 158 individuals. A decreasing linear trend of the secondary attack rates was observed as the age increased. The secondary attack rates were 100% in 28 children aged seven days - six months, 80.85% in 21 children aged six months to five years, 39,74% in 78 children aged 5 to 19 years old and 12,78% in 133 adults older than 19 years old. The secondary attack rates decreased independent of the vaccination status, suggesting a natural acquired immunity. The estimated effectiveness of pertussis vaccination in protecting exposed vaccinated children aged six months to five years old was 12,5% I.C 95% (-5,3 - 27,3) The effectiveness of pertussis vaccine in reducing bacteriologically positive disease was 63.1% I.C 95% (40,7 - 77,0) and in reducing transmission from vaccinated breakthrough cases was 61.6% I.C 95% (12,8 - 83,1). The individuals 11 years of age and older were the source of pertussis transmission to 76% of 25 infants aged six months and younger. Children aged six months and younger are more likely than older children to have severe disease and to require hospitalization. The effectiveness of pertussis vaccination in reducing transmission from vaccinated breakthrough cases and in reducing bacteriologically positive disease is an indirect beneficial effect in the population. A low pertussis vaccine effectiveness obtained in this study suggests that the vaccination is offering little protection and recommend a more methodologically rigorous investigation
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Vera Magalhães da Silveira

School:Universidade Federal de Pernambuco

School Location:Brazil

Source Type:Master's Thesis

Keywords:Pertussis vaccine Vaccine effectiveness National immunization program

ISBN:

Date of Publication:02/28/2005

© 2009 OpenThesis.org. All Rights Reserved.