Erythrocyte Biology and its Impact on Plasmodium vivax Invasion
Malaria infection caused by Plasmodium species parasites is a world problem and the number of infections and deaths are staggering; 500 million and 1 million per year respectively. Although research on malaria has been extensive, a vaccine remains elusive. Characterization of the human erythrocyte proteins and their expression, and how Plasmodium species parasites exploit these proteins to gain entry into erythrocytes is an aspect of research that cannot be overlooked. In this paper, knowledge of erythrocyte biology, protein expression of erythrocytes, and genetic abnormalities of erythrocytes is combined to better understand the invasion biology of Plasmodium vivax malaria. This research may lay the groundwork for future insight into an in vitro culturing system for P. vivax as well as offer insight into vaccine development.
School:Case Western Reserve University
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:plasmodium vivax erythrocyte malaria parasite invasion reticulocyte
Date of Publication:01/01/2008