Endothel und Entzündung Pathomechanismen der bakteriellen Endothelaktivierung

by Hippenstiel, Stefan

Abstract (Summary)
Activation of endothelial cells by bacteria and their products contributed significantly to clinical signs of bacterial infections. Liberation of chemo- and cytokines in concert with expression of adhesion molecules by the endothelium resulted in recruitment of granulocytes. Paracrine and systemic effects of vasoactive agents and cytokines secreted by endothelial cells contributed the regulation of inflammation. Loss of endothelial barrier function induced edema formation. This postdoctoral lecture qualification addressed the molecular interaction of bacteria and their products with endothelial cells. The recruitment of granulocytes, the regulation of endothelial barrier function and activated signalling pathways in endothelial cells were analyzed. Based on these experiments new therapeutic strategies have been tested. In summary, extended these experimental investigations the understanding of bacterial-endothelial interaction.
This document abstract is also available in German.
Document Full Text
The full text for this document is available in German.
Bibliographical Information:


School:Humboldt-Universität zu Berlin

School Location:Germany

Source Type:Master's Thesis

Keywords:Endothel Infection Pathomechanismen Endothelium Bacteria Mechanism


Date of Publication:04/19/2004

© 2009 All Rights Reserved.