Electron Transfer Mechanism And Potential Applications Of ?-Helical Peptides
This thesis also describes investigations in two important areas of applications of the ?-helices. The first is photocurrent generation upon laser excitation of light-harvesting chromophore-functionalised peptides which mimics the natural photosynthetic centre. This important area of research can promote development of nano-scaled photovoltaic devices. Surprisingly, following the conventional experimental protocols, a photocurrent was observed in the absence of a chromophore and even by the irradiation of a bare gold electrode with laser light. It is suggested that an important consequence of laser irradiation has been overlooked in several publications and the so-called photocurrent phenomenon may be a consequence of laser heating.
Peptide-protected nanoparticles is another area of research receiving significant attention these days due to its potential relevance in biomedical applications. However, peptides are highly flexible and their structure can change depending on the nature of the environment. Since the reactivity of a peptide is related to its secondary structure, any conformational change could seriously alter the overall activity of the peptide-protected nanoparticles. In this thesis, the structural investigation of an ?-helical peptide was carried out and it was found that the radius of curvature of nanoparticles has a profound effect on the structure of the adsorbate peptides and thereby, may affect the overall activity of the peptide-protected nanoparticles.
Advisor:Dr. Andrzej Baranski; Dr. Jeffrey T. Banks; Dr. Susan Kaminskyj; Dr. Stephen Foley; Dr. Stephen Urquhart; Dr. Heinz-Bernhard Kraatz
School:University of Saskatchewan
School Location:Canada - Saskatchewan
Source Type:Master's Thesis
Keywords:electron transfer peptide electrochemistry nanoparticles photocurrent
Date of Publication:10/26/2007