THE EFFECTS OF POLYMER BLENDS ON THE RELEASE OF PROPRANOLOL HYDROCHLORIDE
The objective of this work was to study the effect of polymer blends on the release of propranolol hydrochloride. This involved the development and formulation of propranolol hydrochloride matrix tablets with different polymer blends. Anionic polymers, Eudragit S, Eudragit L 100-55, and sodium carboxymethyl cellulose were incorporated in hydroxypropylmethyl cellulose (K100M) in different ratios. The ratio of polymer used were 0:1, 1:3, 1:1, 3:1, and 1:0 HPMC:Anionic polymers (Eudragit S, Eudragit L 100-55 and sodiumcarboxymethyl cellulose). Direct compression was used to produce matrix tablets. The drug release from hydroxypropylmethyl cellulose matrices were examined in water, 0.1NHCl and phosphate buffer pH6.8 using fully automated dissolution apparatus. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers were determined using UV difference spectroscopy. The binding constant of the propranolol hydrochloride anionic polymer complex was obtained from scatchard plot. The rank order of the binding constant was Eudragit L 100-55> NaCMC>Eudragit S. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The ratio of HPMC-anionic polymer also influence the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH independent extended release tablets in water, 0.1 N HCl and ph 6.8 phosphate buffer.Hydroxypropylmethylcellulose blends with anionic polymers can produce pH independent Extended propranolol hydrochloride release but only for 1:1 ratio of Hydroxypropylmethylcellulose and Eudragit L. It should be emphasized that the results although pertinent to propranolol hydrochloride, may not apply to matrices containing salts other than hydrochlorides and probably not to acidic drugs which could not interact with anionic polymer in a similar manner.
School:University of Cincinnati
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:sustained release matrix propranolol hydroxypropylmethyl
Date of Publication:01/01/2001