Effects of fatty acids and over-stimulation on insulin secretion in man

by Qvigstad, Elisabeth

Abstract (Summary)
Objective: To investigate in type II diabetes with hypertriglyceridemia the effects of a short term low-fat diet on lipids, metabolic control, insulin sensitivity and adipocyte hormones. Design: Baseline dietary intake assessed by weighing during two separate 3 day periods 25 followed by a 3 day low-fat dietary intervention. Setting: Out-patient. Subjects: Nineteen subjects, 10 males, 9 females with type II diabetes and triglycerides >2.2 mmol/l at screening. Interventions: Patients were advised to reduce isoenergetically 10 – 15 energy % (E%) from 30 fat. They were to reduce visible fat, use low-fat products, and increase intake of fish and fibre- rich foods. Results: E% from fat was reduced from 39 to 22 (P<0.0001). Total cholesterol decreased to 95 % of baseline (P < 0.011), HDL cholesterol to 97 % (P < 0.083), triglycerides to 91 % (P < 0.055) and the ratio of n-6 to n-3 fatty acids to 76 % (P < 0.001). Blood glucose, fasting 35 insulin and fasting glucose to insulin ratios were unaffected in the whole group. However, glucose/insulin was lower at moderate than at pronounced degree of fat reduction (P < 0.009 for difference between dichotomised groups). Concentrations of leptin decreased to 90 % of baseline (P < 0.013) and of adiponectin to 92 % (P < 0.055). The leptin decrease was unrelated to fat reduction and confined to women. 40 Conclusions: 1) The effects of a clinically relevant reduction in total and saturated fat in type II diabetes vary with gender and degree of fat reduction. 2) Effects on blood lipids and adipocyte hormones are not accompanied by beneficial effects on insulin sensitivity and metabolic control. Sponsorship: University. 3 45 Descriptors: low-fat diet, type II diabetes, insulin sensitivity, leptin, adiponectin, hypertriglyceridemia. 4
Bibliographical Information:


School:Norges teknisk-naturvitenskaplige universitet

School Location:Norway

Source Type:Master's Thesis



Date of Publication:01/01/2003

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