Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains
To determine the effect of genetic factors on training-induced change in glucose tolerance, Copenhagen (COP) and DA rats were studied. After 4 weeks of endurance swim training, an improvement in glucose tolerance was assessed by performing glucose tolerance tests on trained and untrained rats. Intermediate metabolites in tissues and blood were also investigated. DA showed a greater improvement (P<0.05) in glucose tolerance than did COP in response to training. There were no differences in adaptive changes in plasma insulin and C-peptide, muscle oxidative capacity, lipogenic capacity in the liver, blood lipids, or muscle TG between the two strains in response to training. Among variables (hepatic glycogen, triglyceride, and CEACAM1 expression) that showed difference between the two strains, increased hepatic CEACAM1 expression in DA coincided with a large improvement in training-induced glucose tolerance in DA rats, implicating it as the most influential factor on the strain difference seen in glucose tolerance.
School:University of Toledo Health Science Campus
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:exercise training glucose tolerance ceacam1 metabolic intermediates inbred rat strains
Date of Publication:01/01/2007