THE EFFECT OF STEROIDS ON NEUROENDOCRINE FUNCTION IN IMMATURE RATS
The hypothesis tested was that a developmental difference in the effects of estrogen and progesterone on nitric oxide and dopamine influences the steroid-induced luteinizing hormone and prolactin surges. I investigated the stimulatory effects of steroid hormones (estrogen and progesterone) on luteinizing hormone and prolactin secretion in pre-pubertal (4 weeks), peripubertal (6 weeks) and sexually mature (12 & 16 weeks) female rats. Additionally, the effects of L-arginine, on the steroid induced luteinizing hormone and prolactin secretions were examined in peripubertal female rats. I also investigated the regulatory role of steroid hormones on nitric oxide synthase and tyrosine hydroxylase levels in the hypothalamus of pre-pubertal (4 weeks) and sexually mature (12 weeks) female rats. For each age, intact, ovariectomized and ovariectomized plus steroid replaced females were examined. These studies advanced our understanding of the neural regulation of puberty and cyclicity by examining the regulatory role of ovarian steroids on nitric oxide and dopamine and its regulatory role on puberty and the development of cyclicity in females. Importantly, these studies investigated the changes that occur during pubertal development.
School Location:USA - Ohio
Source Type:Master's Thesis
Keywords:steroids luteinizing hormone prolactin nitric oxide dopamine
Date of Publication:01/01/2004