Effect of Long Term Steroids on Cough Efficiency and Respiratory Muscle Strength in Patients with Duchenne Muscular Dystrophy
Abstract (Summary)The effect of long-term steroid (>1 year) therapy on peak cough flow (PCF) in patients with Duchenne muscular dystrophy (DMD) is assessed alongside the pulmonary function (PFT) variable most predictive of PCF. Medical records of 10 steroid treated and 25 untreated DMD patients are analyzed. Forced vital capacity (FVC), maximum expiratory pressure (MEP), maximum inspiratory pressure (MIP), maximum voluntary ventilation (MVV), and PCF data were collected. Groups were compared with Wilcoxon test and predictive relationships assessed with multiple linear regression. PCF (P = 0.047) & MEP (P = 0.021) were higher in the treated patients [PCF values 27 L/min higher than the untreated (95% CI = 2 L/min to 52 L/min, P = 0.033)]. MVV was most predictive of PCF. We concluded that long term steroid therapy may be beneficial to PCF and respiratory muscle strength in DMD. MVV may be a useful predictor of lung function in DMD.
School:University of Cincinnati
School Location:USA - Ohio
Source Type:Master's Thesis
Date of Publication:01/01/2007