Efecto de la amitriptilina sobre la evitación inhibitoria en ratones machos y hembras
Antidepressants are widely prescribed for depression and other disorders like anxiety. Apart from their therapeutic action, these psychotropic medications have side effects. For instance, tricyclic antidepressants have anticholinergic actions considered responsible for learning and memory impairment processes. With the aim of assess amitriptylines effects on memory here we studied its acute and chronic administration on a inhibitory avoidance task in male and female mice. Animals can learn in a sole session (training) that crossing from black side into dark side imply an electric shock; twenty-four hours later (test), control mice avoid crossing to dark side.
In the case of treated mice, in both sexes, acute amitriptyline administration before or immediately after training blocks the inhibitory avoidance acquisition and consolidation, respectively. Chronic daily administration before training also impair this task, but there was absence of effects when the daily treatment started 24 hours after training. Prevention of amitriptyline-induced avoidance impairment by piracetam pre-training (chronic or acute administration) was posible in male but not female mice. Post-training acute administration of caffeine didnt produce any effect in any sex. In the elevated plus-maze exploration, amitriptyline had no effect on anxiety and in some acute doses reduced the activity. The results indicated that amitriptyline cognitive effects were not be mediated by anxiolytic effects.
Advisor:Arenas Mª Carmen; Parra Andrés
School:Universitat de València
Source Type:Master's Thesis
Keywords:psicobiologia i psicologia social
Date of Publication:03/07/2003