Development of methodology to synthesize (S)-nicotine derivatives

by 1973- King, Laura Stuart

KING, LAURA STUART: Development of methodology to synthesize (S)-nicotine derivatives. (Under the direction of Dr. Daniel L. Comins.) N-acylpyridinium salt chemistry was used to synthesize 4 substituted (S)-nicotine derivatives. The intermediate dihydronicotines and the resulting nicotine derivatives serve as potential pharmaceutical and pesticide targets as well as interesting synthetic intermediates. Other methodologies developed synthesize (S)-nicotine-N-oxide. ii Biography The author, Laura S. King, was born in Wilmington, North Carolina on October 2, 1973 to Mr. and Mrs. Horace Thompson King III. She graduated from New Hanover High School in 1991 and continued her education at the University of North Carolina at Chapel Hill. After graduating in 1995 with a Bachelor of Science degree in chemistry, she worked as an intern at the Grocery Manufacturers of America trade association in Washington, D.C. in the science and technology division. She then worked as an assistant scientist at Applied Analytical Industries in Wilmington, North Carolina in the clinical services division and the wet chemistry departments. In addition, she doubled as customer service representative serving as a liaison between the laboratory and clients. In 1999 she worked with a spin-off company, Quality Chemical Laboratories, while attending the University of North Carolina at Wilmington part-time taking graduate chemistry courses. In the spring of 2000, she transferred to North Carolina State University to continue her graduate studies. The author completed her Masters degree in Synthetic Organic Chemistry, under the direction of Dr. Daniel L. Comins, in the spring of 2003. iii