Development of boarding computational and tools for the comparative analysis of genomas microbianos.

by Catanho de, Marcos Paulo

This dissertation deals with the development of computational approaches and tools for large-scale comparative analysis of microbial genomes. We present three complementary, yet independent, systems designed for comparative analyses of microbial genomes in general and mycobacterial genomes particularly: LocalCOG, a relational database system built for local use of data from COG (Clusters of Orthologous Groups); BioParser, a program that offers graphical interfaces for parsing and analysing reports of sequence similarity searches; GenoMycDB, a relational database built for comparative analyses of mycobacterial genomes based on their predicted protein content.