Desarrollo de métodos analíticos para el control de filtros UV de naturaleza orgánica en productos cosméticos para la protección solar.
Damage to the ozone layer has led to an increment in the solar UV radiation reaching
earth, which in turn makes strong protection necessary in order to prevent harmful
effects on human health. The use of sunscreen cosmetics could help to prevent or
minimize these harmful effects.
The analytical control of these products is necessary, since their efficacy and safety
must be guaranteed. However, there are no official analytical methods to be used, and
thus the development of rapid and accurate analytical methods in order to control
sunscreen cosmetics is, without any doubt, of high interest, and this topic is the aim of
this Doctoral Thesis. Special attention has been paid in the development of methods
that use harmless reagents or with low toxicity, and moreover, by reducing the amount
of employed reagents and thus minimizing the volume of waste of products generated,
by proposing friendly (or green) analytical methods for both the environment and
operator in order to fulfil with the current tendency of the analytical chemistry known as
Green Analytical Chemistry.
In this sense, different automated methods based on the use of UV/VIS absorption
spectroscopy, fluorimetry and chemiluminiscence have been proposed. The
automation of the procedures allows increasing the sample throughput. The analytical
features of these methods are very suitable for the analytical control of the UV filters in
the sunscreen cosmetic products.
On the other hand, different methods based on the use of liquid chromatography with
UV/VIS detection have been also proposed, which allow the simultaneous
determination of the worldwide most used UV filters in few minutes. The analytical
features of these methods are also very suitable for monitoring the UV filters in the
Finally, the last chapter of this Doctoral Thesis is focused on the development of an
analytical method able to determine one of the most used UV filter in urine samples
coming from users of sunscreen cosmetic products, in order to study the excretion and
bioaccumulation mechanisms in the human body, and thus providing information on its
possible toxicological side-effects.
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Advisor:Salvador Carreño, Amparo
School:Universitat de València
Source Type:Master's Thesis
Date of Publication:04/07/2003