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Defining the role of the angiotensin ii type 2 receptor in cardiovascular disease [electronic resource] /

by Metcalfe, Beverly Lynn

Abstract (Summary)
ABSTRACT: Abstract of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy DEFINING THE ROLE OF THE ANGIOTENSIN II TYPE 2 RECEPTOR IN CARDIOVASCULAR DISEASE By Beverly L. Metcalfe May, 2004 Chair: Mohan K. Raizada Major Department: Physiology and Functional Genomics Despite recent advances in understanding the renin angiotensin system, the role of the angiotensin II type 2 receptor (AT2R) in cardiovascular diseases remains elusive. Given that the AT2R has been implicated to play a role in embryonic development, traditional transgenic animal models may not be an effective means for studying the role of the AT2R. To overcome the inherent problems of compensatory gene expression with transgenic animals, we developed a lentiviral vector system in which overexpression of the AT2R could be accomplished after embryonic development.
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School:University of Florida

School Location:USA - Florida

Source Type:Master's Thesis

Keywords:research cardiovascular diseases angiotensin ii lentivirus hypertension

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