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COUPLED OXYGEN TRANSPORT ANALYSIS IN THE AVASCULAR WALL OF A CORONARY ARTERY STENOSIS DURING ANGIOPLASTY

by VAIDYA, VINAYAK S

Abstract (Summary)
The coupled oxygen transport in the avascular wall of a coronary artery is studied by numerically solving the convection-diffusion equations. Initially, the analysis is in an unstenosed artery. Further, the geometry is modified to replicate residual stenosis after percutaneous transluminal coronary angioplasty (post-PTCA). The analysis is also done for pre-PTCA stenosis geometry and the results are compared with those for post-PTCA stenosis. Important physiological aspects, such as oxygen consumption in the wall, oxygen carried by the hemoglobin, non-Newtonian viscosity of the blood, and supply of oxygen from the vasa vasorum are included. Mean blood flow rate in the lumen is varied from basal to hyperemic conditions. The results show that the Po2 in the medial region of the arterial wall is ~10 mmHg. The oxygen flux to the wall increases in the flow acceleration region, whereas it decreases at the flow reattachment zone. Near the location of flow separation there is a small rise and a sharp fall in the oxygen flux. The minimum Po2 in the avascular wall, Po2,min, at the point of flow reattachment decreases to ~6 mmHg for a 300 micron wall thickness. For a thinner wall of 200 micron, the Po2,min at the location of flow reattachment increases to 6 times that of a 300 micron wall. The Po2,min in the wall decreases by 60% when volumetric oxygen consumption rate is increased by 30% for the same avascular wall thickness. The drop in the oxygen flux at the location of flow reattachment for pre-PTCA stenosis is 4 times that of post-PTCA stenosis. The drop in Po2 along lumen-endothelium interface, Po2,w, at the location of flow reattachment for pre-PTCA stenosis is 2 times that of post-PTCA stenosis.
Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:coronary artery oxygen transport avascular wall angioplasty blood

ISBN:

Date of Publication:01/01/2005

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