Contribution to the prognostic assessment of patients with advanced lung adenocarcinoma: evaluation by immunohistochemical methods of thyroid transcription factor-1 and matrix metalloproteinase-9
The prognostic value of Thyroid Transcription Factor-1 (TTF-1) and Matrix Metalloproteinase-9 (MMP-9) tumor expression was evaluated in 51 patients with advanced lung adenocarcinoma. Poor performance status (P = 0.017), low TTF-1 (P = 0.001), and high MMP-9 (P = 0.008) were independent prognostic factors. There was three risk groups: low risk (TTF-1 > 40% and MMP-9 < 80%; median survival: 127.6 wk), intermediate risk (TTF-1 < 40% or MMP-9 > 80%; median survival: 39.0 wk), and high risk (TTF-1 < 40% and MMP-9 > 80%; median survival: 16.4 wk). Evaluation of TTF-1 and MMP-9 may allow us to identify different, clinically meaningful, prognostic groups of lung adenocarcinoma patients.
Advisor:Teresa Yae Takagaki; Carmen Silvia Valente Barbas; Jorge Sabbaga; Ilka Lopes Santoro; Hakaru Tadokoro; Teresa Yae Takagaki
School:Universidade de São Paulo
Source Type:Master's Thesis
Keywords:adenocarcinoma immunohistochemistry/methods lung neoplasms/pathology metalloproteins metaloproteínas survival analysis
Date of Publication:04/28/2005