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Contribution à l'étude du pouvoir immunomodulateur des bifidobactéries: analyse in vitro et étude ex vivo des mécanismes moléculaires impliqués

by Amrouche, Tahar

Abstract (Summary)
Bifidubaktiri d iprubyuteken (probiotiques) i yetwassnen atas assagi, ye?ni ?-?ibaktiryin mara twarnunt i tgulliyin ??akent ayen yelhan i tdawsa. Tibaktiriyin agi zemrent ad snernint kra n tsu?nin ye?huddun ?ef tfekka mgal atanan n u?ebbud d izerman n bnadem. D acu kan, ar assa, ur nessin ara amek tibaktiriyin stanent tafekka. Iswi n usenfar agi d anelmud n unezmar n usnerni n ustan n bifidubaktiri. Ayagi i wakken a d-naf isemduyen n kra n tsegrin n tsiluliyin (cellules) am iferdisen (éléments) yellan daxel, s-ufella ne? i d-deggirent ar berra ?ef tririt n uhuddu. Krad (3) n ccetlat n bifidubaktiri id-yekkan seg izerman llufan ?walmendent ?wasdemrent ar yiwet n ccetla tamsel?ut Bifidobacterium lactis Bb12. Agmuden i d-nessufe? qqaren-d d akken asnerni yelhan n ufadi n tsiluliyin n udihan (rate) n amumad, i d- yettaba? unerni amuqran n IFN-? yakw d usennerni n usufe? (sécrétion) n IL-10, yefkaten-id ulesi n tsilulit (paroi cellulaire). Ayen yellan daxel n tsilulit d tazunin-ines (ipeptidiyen yak tiprutiniyin) snernayent drus ?ef ulesi. Ma d ayen y?enan EPS (exopolysaccharides) ulac asnnerni i d-yekkan segsen. Ma d tiprutiniyin n ulesi n bifidubakiri (B. animalis, B. breve, B. longum, B. infantis, B. bifidum et B. pseudolongum) banent-ed d timesnerniyin timuqranin n uhareb ?ef tfekka n umumad (Balb/c) ssutuyent afares amuqran n tfekkamgalin. Tifekkamgalin i d-yeff?en d yiwet n txellalt (IgG) mgal B. longum ?wafursent-ed s trennawet u sknent-ed tasedmirt tanmidagt (réaction croisée) yakw d ccetlat nniden n bifidubakiri. Anecta yekka-d seg yiwet n teprutint (protéine) tamsihart i yezzayen 58 kd. Tulmist n tfekkamgalin i d-yefursen ye?wasentem-ed s usadez (test) ibaw i d- yelummzen mi ?-ner?ed yakkw d cctali nniden n tbaktiriyin. Tufin n bifidubaktiri yeddren s tfekkamgalin i d-yedran yefursen yedra-d s usadez n immuno-culture. Tifekkamgalin tulmisin i-d yekkan seg yiwet n txellayt id-nessenfel zemrent ad ?waqedcent i tifin n cctali n bfidobktiri di tgwellyin.
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Bibliographical Information:

Advisor:Fliss, Ismail; Boutin, Yvan

School:Université Laval

School Location:Canada - Quebec / Québec

Source Type:Master's Thesis

Keywords:agriculture

ISBN:

Date of Publication:07/01/2005

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