Chemoreflex modulation by hypoxia and hypercapnia through submaximal exercise in heart failure patients

by Zytynski Moura, Lidia Ana

Abstract (Summary)
Heart failure(HF) dyspnea is complex with potential enrolment of central(CC) and peripheric chemoreceptors(PC).We investigated CC and CP behavior through submaximal exercise in 15 HF patients and 7 normal subjects in treadmill 6-minute cardiopulmonary walking tests:isocapnic hypoxia(HPO), hypercapnia hyperoxic(HCP) and room air.HPO increased:ventilation(VE) with acute ventilatory response(AVR), heart rate (HR) and O2 uptake and reduced dead space, distance walked (DW) and systemic blood pressure(SBP).The HPC improved VE above HPO level with AVR. PC have greater action on HR and SBP than CC,despite their largest sympathetic activation. PC have faster impulse on VE although be lowest than CC
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Edimar Alcides Bocchi; Dirceu Rodrigues de Almeida; Paulo Roberto Slud Brofman; Fabio Fernandes; Maria da Consolação Vieira Moreira; Edimar Alcides Bocchi

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis



Date of Publication:08/22/2005

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