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CHARACTERIZATION OF NEUTRALIZING RESPONSES TO ANTHRAX TOXINS AND ISOLATION AND CHARACTERIZATION OF THE SHIGA-TOXIN ENCODING PHAGE OF ESCHERICHIA COLI 0157:H7

by HANSON, JAMES F

Abstract (Summary)
The ability of an organism to cause infection or disease is related to a variety of factors, including the general health of the host. Bacillus anthracis is the organism responsible for anthrax, a disease most commonly associated with people who work with animals, but recently has been designated a bioterrorism agent. The organism uses a polysaccharide capsule and secretes three toxins in order to avoid and disable the host’s immune response. I characterized the protective nature of the immune response of recipients of the anthrax vaccine. Escherichia coli O157:H7 is the causative agent of enterohemorrhagic colitis, a bowel disease associated with watery and bloody diarrhea. The organism’s genome is lysogenized by a bacteriophage, which encodes Shiga toxin. Shiga toxin is produced when the phage enters the lytic cycle. I characterized the physical properties of a toxin-deleted derivative from bacteriophage isolated from clinical samples.
Bibliographical Information:

Advisor:

School:University of Cincinnati

School Location:USA - Ohio

Source Type:Master's Thesis

Keywords:anthrax lethal toxin protective antigen escherichia coli o157 h7 shiga

ISBN:

Date of Publication:01/01/2004

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