Bone disease in primary glomerulophaty

by Dias, Cristiane Bitencourt

Abstract (Summary)
The objective of this study was to analyze bone metabolism in proteinuria glomerular patients not having previously used drugs affecting bone metabolism. Seventeen patients were studied with histomorphometric analysis of bone biopsies and bone fragments were obtained for cell culture (n = 13), in which we evaluated osteoblastic proliferation. Comparing patients to controls of literature indicate reduced bone remodeling and altered bone microarchitecture. In corroboration, mean osteoblast proliferation was lower in patient samples when compared with those for normal osteoblasts obtained from age-matched, gender-matched donor organs (n = 5). Concentrations of 25-hydroxyvitamin-D3 correlated negatively with proteinuria and positively with osteoblast proliferation in culture
This document abstract is also available in Portuguese.
Bibliographical Information:

Advisor:Viktoria Woronik; Maria Almerinda Vieira Fernandes Ribeiro Alves; Emmanuel de Almeida Burdmann; Maria Cristina Ribeiro de Castro; Marcio Dantas; Viktoria Woronik

School:Universidade de São Paulo

School Location:Brazil

Source Type:Master's Thesis

Keywords:Alkaline phosphatase Biopsy Bone diseases Calcifediol Cell culture Nephrotic syndrome Parathyroid hormone Proteinuria Vitamin D


Date of Publication:04/13/2006

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