Details

Biomimetic Iron Complexes involved in Oxygenation and Chlorination :A Theoretical Study

by Noack, Holger, PhD

Abstract (Summary)
Biomimetic chemistry is directed towards the simulation of enzymatic reactivity with synthetic analogues. In this thesis a quantum chemical method has been employed to study the mechanism of highly reactive iron-oxo complexes involved in oxygenation and chlorination of organic substrates. The aim of this research is to gain greater understanding for the reactivity paradigm of the iron-oxo group.One reaction deals with the conversion of cyclohexane into adipic acid, a key chemical in industrial chemistry, catalyzed by an iron(II)-porphyrin complex in the presence of dioxygen. This process constitutes a ’green’ alternative to conventional adipic acid production, and is thus of great interest to synthetic chemistry. Another reaction investigated herein regards the selective chlorination observed for a new group of non-heme iron enzymes. With help of theoretical modeling it was possible to propose a mechanism that explains the observed selectivity. It is furthermore demonstrated how a biomimetic iron complex simulates the enzymatic reactivity by a different mechanism.Other topics covered in this thesis regard the structure-reactivity relationship of a binuclear iron complex and the intradiol C-C bond cleavage of catechol catalyzed by an iron(III) complex.
Bibliographical Information:

Advisor:

School:Stockholms universitet

School Location:Sweden

Source Type:Doctoral Dissertation

Keywords:NATURAL SCIENCES; Chemistry; Inorganic chemistry; Bio-inorganic chemistry; NATURAL SCIENCES; Chemistry; Theoretical chemistry; biomimetic; iron; density functional theory; intradiol; chlorination; adpic acid; diamond core; reactivity; Chemical Physics; kemisk fysik

ISBN:978–91–7447–013–0

Date of Publication:01/01/2010

© 2009 OpenThesis.org. All Rights Reserved.