Assessment of the Effect of Cancer and its Treatment on PET Scan F-18 Tracer Distribution in Pre- and Post-treatment and its Relation to Myocardial Tissue Uptake
Abstract (Summary)The general objective was to study the effect of cancer and the its treatment on the Positron Emission Tomography scan F-18 FDG tracer distribution in pre-and post- treatment and its relation to myocardial tissue uptake. The 39 subjects studied were patients with cancer who had a PET imaging evaluation for the disease process and who had their treatment for cancer. They were followed up with regular PET scan imaging. Following treatment FDG was administered as per standard imaging protocol in the diagnosis of the cancer and the uptakes in the cancer tissue site and the cardiac site were measured and studied. The standard uptake values were used as a reference of tissue activity was a found that there was a trend of decrease tumor uptake as treatment progressed, and generally an increase in the cardiac uptake. This increased cardiac uptake is likely due to decreased FDG “steal” by the tumor.
School Location:USA - Ohio
Source Type:Master's Thesis
Date of Publication:01/01/2005