Aspectos analíticos y epidemiológicos de la infección por virus de la Hepatitis C con donantes de sangre de la Comunidad Valenciana entre 1990 y 2002.
ABSTRACT In the period 1991-2002 the prevalence for HCV infection in the population of blood donors of the Valencian Region has dropped 66%, being in the last year (2002) around 0.27%. As the incidence rate of the infection for HCV in the Valencian blood donors has been reduced in the period of study 30 times, reaching 3.4x105 donor-years in 2002, the residual risk has also dropped in this period, being of 1.12x106 donations in 2002. Among the different provinces of the Valencian Region there are significant differences on annual prevalence, being the provinces of Valencia and Castellón higher than the province of Alicante (p<0.05) in the period 1991-1999. On the other hand, in the period 2000-2002 the prevalence of HCV in the three provinces have been similar. Along the period 1990-2002, the prevalence, incidence and residual risk of transmission of HCV have continued dropping. The decrease of the residual risk has taken place partly due to the increase of sensibility in the screening tests. The exclusion of the donors with risk of transmitting the HCV infection and the public awareness of infection has probably contributed to the descent of the prevalence and incidence rates. As regards the antibodies detection test used in the study, the specificity of screening serologic test of third generation (99.84%) for detection of the Hepatitis C Virus (HCV) has been higher than that of second generation test (p<0.05). About the confirmation serologic test, the proportion of indeterminate results obtained with the second and third generation test has been similar (25-30%). The introduction screening genomic test (NAT) in our center has not been difficult, the window period of the infection for HCV has been reduced and thus, the residual risk. Between 1999 and 2006, the observed yield with the introduction of the genomic test for detection of the HCV in the Valencian Region, has been 1:320000. This observed yield has been similar to the expected yield by NAT test between 2000 and 2002. Due to the implementation of the NAT screening test in blood donations, the alanine aminotransferase (ALT) quantification test for the detection of HCV in the initial phases of the illness is unneccessary.
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Advisor:Álvarez Do Campo, Manuel; Planelles Silvestre, Dolores
School:Universitat de València
Source Type:Master's Thesis
Date of Publication:05/26/2008