Analogues of Natural Product-like Scaffolds: Synthesis of Spiroacetal Derivatives

by Choi, Ka Wai

Abstract (Summary)
Diversity-oriented synthesis (DOS) involves the synthesis of several synthetic targets by transforming a collection of structurally simple and similar starting materials into a collection of structurally more complex and diverse products. This thesis describes the elaboration of a 6,6-spiroacetal scaffold to incorporate biologically useful moieties, in particular nucleobases, triazoles and amino acids, thus generating a collection of novel hybrid structures. The research reported, herein, focused on the synthesis of spiroacetal-nucleosides, triazoles and amino acids bearing a C8?-hydroxymethyl substituent.
Bibliographical Information:

Advisor:Professor Magaret Brimble

School:The University of Auckland / Te Whare Wananga o Tamaki Makaurau

School Location:New Zealand

Source Type:Master's Thesis

Keywords:chemistry spiroacetal nucleosides triazoles fields of research 250000 chemical sciences


Date of Publication:01/01/2008

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