Alteraciones vasculares en la insuficiencia renal crónica. Papel del endotelio.
Uremia is an established risk factor for cardiovascular and cerebrovascular accidents. Hemodialysis improves the lifes quality of these patients, but this treatment also produces vascular alterations.
We examined the relaxant and contractile response in forearm veins from patients with chronic renal failure before hemodialysis, on chronic hemodialysis and in veins obtained from donors (controls).
We study the role of vasodilator prostaglandins (PGI2), nitric oxide (NO) and endothelium derived hyperpolarizing factor (EDHF). The contribution of these factores is diminished in chronic renal failure. This effect might contribute to, or even cause, some of the vascular features of this condition. Hemodialysis improves the endothelial function because of an augmented participation of EDHF.
The study of gene expression showed a metabolic failure in the enzyme that degrades the uremic toxins. The low expression of this enzyme, dimethylarginine dimethylamino hydrolase (DDAH), could explain some vascular features and could be a therapeuthic strategy for improving lifes quality of these patients.
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Advisor:Segarra Irles, Gloria Vta.; Vila Salinas, José M.; Martínez León. Juan B.
School:Universitat de València
Source Type:Master's Thesis
Date of Publication:05/17/2007