Adoptive transfer studies to establish a model of phase ii exocrine gland dysfunction in the nod model of sjogren's syndrome [electronic resource] /
ABSTRACT: ABSTRACT: Sjo umlautgren?s Syndrome (SjS) is an autoimmune exocrinopathy that results in the development of xerostomia (dry mouth) and keratoconjunctivitis (dry eyes). There are two distinct phases of SjS. Phase I which is lymphocyte independent and phase II which is lymphocyte-dependent. The non-obese diabetic (NOD/LtJ) mouse displays symptoms associated with both phases of the disease and, therefore, is a useful model for studying SjS. The insertion of the scid mutation into the NOD/LtJ background has led to the development of the NOD.CB17-PrkdcScid/J (scid). The scid mouse develops phase I of SjS but as a result of the absent lymphocytes, development of phase II does not occur. The lack of mature lymphocyte development in the scid allows it to be used as a recipient in adoptive transfer studies to determine the combination of lymphocytes required to induce phase II of SjS.
School:University of Florida
School Location:USA - Florida
Source Type:Master's Thesis
Keywords:research sjogren s syndrome models animal mice scid
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